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2140807-23-2

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2140807-23-2 Structure

2140807-23-2 Structure
IdentificationBack Directory
[Name]

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-
[CAS]

2140807-23-2
[Synonyms]

H-Isoindole-1
Thalidomide-NH-PEG3-OH
Pomalidomide-NH-PEG3-OH
Thalidomide-NH-C2-PEG3-OH
6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-
2-(2,6-dioxopiperidin-3-yl)-4-((2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)amino)isoindoline-1,3-dione
H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-
[Molecular Formula]

C21H27N3O8
[MDL Number]

MFCD32903299
[MOL File]

2140807-23-2.mol
[Molecular Weight]

449.45
Chemical PropertiesBack Directory
[Boiling point ]

706.3±60.0 °C(Predicted)
[density ]

1.390±0.06 g/cm3(Predicted)
[pka]

10.74±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1].
[Biological Activity]

Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1]. XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].
[IC 50]

Cereblon
[References]

[1]. Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186.
Spectrum DetailBack Directory
[Spectrum Detail]

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-(2140807-23-2)1HNMR
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