ChemicalBook--->CAS DataBase List--->2143933-81-5

2143933-81-5

2143933-81-5 Structure

2143933-81-5 Structure
IdentificationBack Directory
[Name]

ICG-Mal
[CAS]

2143933-81-5
[Synonyms]

ICG-Mal
ICG maleimide,ICG-MAL
[Molecular Formula]

C51H56N4O6S
[MOL File]

2143933-81-5.mol
[Molecular Weight]

853.09
Chemical PropertiesBack Directory
[solubility ]

DMSO (with sonication)
[form ]

Solid
[color ]

Green to dark green
[Appearance]

dark green powder
[InChIKey]

GZXGSACLFNPENZ-UHFFFAOYSA-N
[SMILES]

CC1(C(=[N+](CCCCS([O-])(=O)=O)C2C=CC3=CC=CC=C3C1=2)C=CC=CC=CC=C1C(C2C3=CC=CC=C3C=CC=2N1CCCCCC(=O)NCCN1C(C=CC1=O)=O)(C)C)C
Hazard InformationBack Directory
[Description]

Indocyanine Green (ICG, IC Green, Foxgreen) is a negatively charged tricarbocyanine dye widely used for imaging and flow cytometry due to its low toxicity and near-infrared fluorescence emission.


ICG has an absorption maximum at 787 nm with slight absorption in the visible range and a fluorescence emission maximum at 819 nm. The minimal light scattering and low autofluorescence in this spectral range result in a significantly reduced background and improved signal-to-noise ratios, thereby enhancing detection sensitivity.


ICG maleimide is a thiol-reactive dye for labeling of protein SH groups, and it can be used to attach ICG fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules (such as thiol-containing oligonucleotides). Cystines should be reduced with TCEP (tris-carboxyethylphosphine) or with another appropriate reductant prior to the labeling.

[Uses]

ICG Maleimide is thiol reactive near infrared (NIR) fluorescent dye and used to generate a stable fluorescence signal in bioimaging.
[Abs/Em Maxima]

787/819 nm
[Fluoresene quantum yield]

0.09
[Extinction Coefficient]

232000
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