| Identification | Back Directory | [Name]
D-Biotin-PEG6-Thalidomide | [CAS]
2144775-48-2 | [Synonyms]
Biotin-PEG6-Thalidomide
D-Biotin-PEG6-Thalidomide
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[20-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2,6-dioxo-1-piperidinyl]-3,6,9,12,15,18-hexaoxaeicos-1-yl]hexahydro-2-oxo-, (3aR,4R,6aS)-rel- | [Molecular Formula]
C37H53N5O12S | [MDL Number]
MFCD31561114 | [MOL File]
2144775-48-2.mol | [Molecular Weight]
791.91 |
| Hazard Information | Back Directory | [Description]
D-Biotin-PEG6-Thalidomide is a cereblon affinity probe for PROTAC and targeted protein degradation research. It can be used in cereblon (CRBN) binding and displacement assays for protein degrader validation experiments, CRBN ligand discovery, competition analyses, or where enrichment of CRBN complexes is required. The hydrophilic PEG spacer increases the solubility of a compound in aqueous media. | [Uses]
Biotin-PEG6-Thalidomide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
Cereblon | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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