| Hazard Information | Back Directory | [Uses]
Antidiabetic agent 5 (compound S1) is a antidiabetic agent. Antidiabetic agent 5 inhibits the activity of α-glucosidase and α-amylase with IC50 values of 3.91，8.89 μM，respectively. Antidiabetic agent 5 decreases sugar levels. Antidiabetic agent 5 has the potential for the research of type-II diabetes[1]. | [in vivo]
Antidiabetic agent 5 (3.9，7.8 mg/kg) can reduce blood glucose levels in diabetic mice[1]. | Animal Model: | 26-33 g, BALB/c mice (diabetes)[1] | | Dosage: | 3.9, 7.8 mg/kg | | Administration: | | | Result: | Exhibited a good biochemical profile with lower sugar level (110–115 mg/dL), increased insulin level (25–30 μM/L), and low level of cholesterol (85 mg/dL) and creatinine (0.6 mg/dL) in blood. |
| [References]
[1] Taj S, et al. The antihyperglycemic potential of pyrazolobenzothiazine 1, 1-dioxide novel derivative in mice using integrated molecular pharmacological approach. Sci Rep. 2024 Apr 2;14(1):7746. DOI:10.1038/s41598-023-49932-2 |
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