| Identification | Back Directory | [Name]
Spiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepine], 6'-(4-chlorophenyl)-1'-methyl-8'-(1H-pyrazol-4-yl)- | [CAS]
2154358-11-7 | [Synonyms]
CFT-2718
Spiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepine], 6'-(4-chlorophenyl)-1'-methyl-8'-(1H-pyrazol-4-yl)- | [Molecular Formula]
C22H17ClN6 | [MOL File]
2154358-11-7.mol | [Molecular Weight]
400.86 |
| Chemical Properties | Back Directory | [Boiling point ]
688.0±65.0 °C(Predicted) | [density ]
1.52±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.44±0.50(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718. | [References]
[1] Sun D, et al. Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models. Mol Cancer Ther. 2021 Aug;20(8):1367-1377. DOI:10.1158/1535-7163.MCT-20-0831 |
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