| Identification | Back Directory | [Name]
Pyrimidine, 5-fluoro-2,4-bis(2-propyn-1-yloxy)- | [CAS]
2155827-07-7 | [Synonyms]
Bis-Pro-5FU
Pyrimidine, 5-fluoro-2,4-bis(2-propyn-1-yloxy)- | [Molecular Formula]
C10H7FN2O2 | [MOL File]
2155827-07-7.mol | [Molecular Weight]
206.17 |
| Hazard Information | Back Directory | [Uses]
Bis-Pro-5FU (Compound 4) is a 5-FU precursor that confers oral bioavailability and increase the safety profile of 5-Fluorouracil (5-FU) chemotherapy regimens. 5-FU is an antineoplastic antimetabolite that is widely used for the research of colorectal and pancreatic cancer[1]. | [References]
[1] Catherine Adam,?et al. A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry?In Vitro?and?In Vivo. J Med Chem.?2022 Jan 13;65(1):552-561. DOI:10.1021/acs.jmedchem.1c01733 |
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