| Identification | Back Directory | [Name]
Pyridine, 2-methyl-3-[5-(methylthio)-1,3,4-oxadiazol-2-yl]-6-(trifluoromethyl)- | [CAS]
215655-21-3 | [Synonyms]
ICT5040
Pyridine, 2-methyl-3-[5-(methylthio)-1,3,4-oxadiazol-2-yl]-6-(trifluoromethyl)- | [Molecular Formula]
C10H8F3N3OS | [MDL Number]
MFCD00816607 | [MOL File]
215655-21-3.mol | [Molecular Weight]
275.25 |
| Hazard Information | Back Directory | [Description]
ICT5040 is a CXCR4 antagonist. | [Uses]
ICT5040 is a small molecule CXCR4 antagonist (IC50=3.8 μM). ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells[1]. | [IC 50]
CXCR4: 3.8 μM (IC50) | [References]
[1] Vinader V, et al. Discovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists. PLoS One. 2013 Oct 18;8(10):e78744. DOI:10.1371/journal.pone.0078744 |
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