| Chemical Properties | Back Directory | [Boiling point ]
591.0±50.0 °C(Predicted) | [density ]
1.677±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (113.10 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
7.66±0.36(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Chst15-IN-1 is a potent reversible covalent Chst15 inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely related glycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selective sulfotransferase inhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair[1]. | [in vivo]
Chst15-IN-1 (3.0 mg/kg; i.v.) has a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 hours[1]. | Animal Model: | Rats | | Dosage: | 3.0 mg/kg (Pharmacokinetic Analysis) | | Administration: | I.v. | | Result: | Had a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 h.
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| [References]
[1] Cheung ST, et al. Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation. ACS Chem Biol. 2017;12(12):3126-3133. DOI:10.1021/acschembio.7b00885 |
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