| Identification | Back Directory | [Name]
MCL-1/BCL-2-IN-3 | [CAS]
2163793-55-1 | [Synonyms]
MCL-1/BCL-2-IN-3
MCL 1/BCL 2 IN 3,MCL1/BCL2IN3
Hexanoic acid, 6-[[2-[6-[(4-bromophenyl)thio]-1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl]ethyl]amino]-6-oxo-, methyl ester | [Molecular Formula]
C27H25BrN2O5S | [MDL Number]
MFCD32263422 | [MOL File]
2163793-55-1.mol | [Molecular Weight]
569.47 |
| Chemical Properties | Back Directory | [Boiling point ]
769.3±60.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 17.86 mg/mL (31.36 mM) | [form ]
Solid | [pka]
15.55±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
MCL-1/BCL-2-IN-3 (Compound 2) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectively[1]. | [References]
[1] Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163. DOI:10.1021/acs.jmedchem.9b00919 |
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