| Identification | Back Directory | [Name]
TETRAETHYL PYROPHOSPHITE | [CAS]
21646-99-1 | [Synonyms]
TETRAETHYL PYROPHOSPHITE
Oxybis(diethoxyphosphine)
Bis(diethoxyphosphino) ether
Tetraethyl pyrophosphite 96%
Tetraethyl pyrophosphite,93%,tech.
Diphosphorous acid tetraethyl ester
TETRAETHYL PYROPHOSPHITE, TECH., 93%
Bis(phosphorous acid diethyl)anhydride
Oxybis(phosphonous acid diethyl) ester | [EINECS(EC#)]
244-494-8 | [Molecular Formula]
C8H20O5P2 | [MDL Number]
MFCD00009082 | [MOL File]
21646-99-1.mol | [Molecular Weight]
258.19 |
| Chemical Properties | Back Directory | [Appearance]
clear colorless liquid | [Boiling point ]
79-81 °C1 mm Hg(lit.)
| [density ]
1.057 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.434(lit.)
| [Fp ]
>230 °F
| [solubility ]
Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly) | [form ]
Oil | [color ]
Colourless |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless liquid | [Uses]
Tetraethyl Pyrophosphite is used as a reagent in the preparation of peptides and in the phosphonylation of carbonyl compounds. | [Uses]
The product can be used as a reagent for peptide synthesis. | [Application]
Tetraethyl pyrophosphite can be used in peptide synthesis; phosphonylation of ketones, aldehydes, and perfluoroalkyl iodides. | [Preparation]
The most convenient method involves the reaction of diethyl phosphite with diethyl phosphorochloridite. Diethyl phosphorochloridite (223 g) is added rapidly to a solution of diethyl phosphite (138 g) and triethylamine (101 g) in benzene (200 ml). The mixture is filtered and the benzene removed by distillation at reduced pressure. The product is isolated by further distillation at reduced pressure (79-81 °C/0.15 mmHg) in 41% yield. |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Acros Organics
|
| Tel: |
+32 14/57.52.11 |
| Website: |
www.acros.be |
|