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N3-D-Orn(Boc)-OH is a Boc-protected pentanoic amino acid derivative, can be used as a click chemistry reagent and has been used to synthesis antibody-drug conjugates (ADC)[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. | [References]
[1] Remon VAN GEEL, et al. Conjugates of antibodies an immune cell engagers. WO2021144315A1
[2] Sandeep Tharian Koshy, et al. Compositions and methods for in vivo generation of car expressing cells.WO2022040586A2 |
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