| Identification | Back Directory | [Name]
ANTI-HDAC4 | [CAS]
NoCAS | [Synonyms]
HD4
HDACA
HDAC-A
HA6116
KIAA0288
ANTI-HDAC4
HDAC-4 human
Histone deacetylase A
Histone deacetylase 4
ANTI-HDAC4 (129-137), HUMAN
ANTI-HDAC4 (129-137) RABBIT PAB
Anti-HDAC4 antibody produced in rabbit
ANTI-HISTONE DEACETYLASE 4 (129-137), HUMAN
ANTI-HISTONE DEACETYLASE 4 (129-137) RABBIT PAB
Monoclonal Anti-HDAC4 antibody produced in mouse
ANTI-HISTONE DEACETYLASE 4 (129-137), HUMAN (RABBIT)
Anti-Histone Deacetylase 4 (HDAC4) (DM-15) antibody produced in rabbit | [MDL Number]
MFCD03455095 |
| Hazard Information | Back Directory | [Uses]
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. | [Biological Activity]
Histone deacetylase 4 (HDAC4) contains import and export nuclear signal th at aids in nucleocytoplasmic shuttling. It has physical and functional interactions with transcription factor myocyte enhancer factor-2 (Mef2) protein and 14-3-3. This interaction disturbs nucleocytoplasmic shuttling and then guides HDAC4 to the cytoplasm and the nucleusrespectively. In additionHDAC4 with HDAC5 and HDAC7 represses transcription by binding to the nuclear receptor co-repressors silencing mediator of retinoic acid and thyroid hormone receptors (SMRT) and nuclear receptor co-repressor (NCOR).''Studies show th at HDAC4 contains a composed import and export nuclear signal th at aids in nucleocytoplasmic shuttling. It has physical and functional interactions with transcription factor MEF2C and 14-3-3. This interaction results in the shuttling and it guides HDAC4 to the cytoplasm and the nucleus.The C-terminal domain of HDAC4 shows innate histone deacetylase activity. It is seen th at MEF2C combines |
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