| Identification | Back Directory | [Name]
EPSILON-AMANITIN | [CAS]
21705-02-2 | [Synonyms]
EPSILON-AMANITIN
α-Amanitin, 1-L-aspartic acid-3-[(4S)-4-hydroxy-L-isoleucine]-
Cyclo[L-Asp-L-t4Hyp-[(4S)-4-hydroxy-L-Ile-]-6-hydroxy-L-Trp2(1)-Gly-3-methyl-L-Nva-Gly-3-oxomercapto(1)-L-Ala-] | [Molecular Formula]
C39H53N9O14S | [MDL Number]
MFCD01747008 | [MOL File]
21705-02-2.mol | [Molecular Weight]
903.96 |
| Hazard Information | Back Directory | [Uses]
ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II[1][2]. | [IC 50]
Traditional Cytotoxic Agents | [References]
[1] Jan Grunewald, et al. Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase. WO2016071856A1.
[2] Kaya E, et al. Amanitin and phallotoxin concentration in Amanita phalloides var. alba mushroom. Toxicon. 2013;76:225-233. DOI:10.1016/j.toxicon.2013.10.008 |
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