| Identification | Back Directory | [Name]
Benzoic acid, 4-[4-[3-[[(4-methylphenyl)sulfonyl]oxy]propyl]-1H-1,2,3-triazol-1-yl]-, methyl ester | [CAS]
2171519-89-2 | [Synonyms]
inhibit,transcription,p53,gankyrin,Inhibitor,DNA damage,cjoc42,MDM-2/p53
Benzoic acid, 4-[4-[3-[[(4-methylphenyl)sulfonyl]oxy]propyl]-1H-1,2,3-triazol-1-yl]-, methyl ester | [Molecular Formula]
C20 H21 N3 O5 S | [MOL File]
2171519-89-2.mol | [Molecular Weight]
415.46 |
| Chemical Properties | Back Directory | [Boiling point ]
616.3±65.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [form ]
Solid | [pka]
-0.06±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Cjoc42 is a compound capable of binding to gankyrin. Cjoc42 inhibits gankyrin activity in a dose-dependent manner. Cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin. Cjoc42 restores p53-dependent transcription and sensitivity to DNA damage[1]. | [References]
[1] Chattopadhyay A, et al. Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell. Sci Rep. 2016;6:23732. DOI:10.1038/srep23732 |
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