| Identification | Back Directory | [Name]
N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide | [CAS]
217171-01-2 | [Synonyms]
PD 173212
N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide
L-Tyrosinamide, N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)- | [Molecular Formula]
C38H53N3O3 | [MDL Number]
MFCD12828777 | [MOL File]
217171-01-2.mol | [Molecular Weight]
599.85 |
| Chemical Properties | Back Directory | [Boiling point ]
753.4±60.0 °C(Predicted) | [density ]
1.053±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: 100 mM; Ethanol: 100 mM | [form ]
Powder | [pka]
13.83±0.46(Predicted) | [color ]
White to off-white | [InChIKey]
GCDHMGROXQUFNR-HEVIKAOCSA-N | [SMILES]
O=C([C@@H](NC([C@@H](N(C)CC1=CC=C(C=C1)C(C)(C)C)CC(C)C)=O)CC2=CC=C(OCC3=CC=CC=C3)C=C2)NC(C)(C)C |
| Hazard Information | Back Directory | [Description]
PD 173212 is an N-type calcium channel blocker (IC50 = 36 nM). It prevents audiogenic seizures in mice when administered at a dose of 30 mg/kg. | [Uses]
PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays. | [in vivo]
PD173212 (30 mg/kg, i.v.) shows moderate efficacy in preventing tonic seizures in the audiogenic seizure model[1]. | [References]
[1] Hu LY, et al. Structure-activity relationship of N-methyl-N-aralkyl-peptidylamines as novel N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2151-6. DOI:10.1016/s0960-894x(99)00359-5 |
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