| Identification | Back Directory | [Name]
E3 Ligase Ligand-Linker Conjugates 58 | [CAS]
2172820-14-1 | [Synonyms]
VH032-PEG5-COOH
(S,R,S)-AHPC-PEG5-COOH
VH 032 amide-PEG5-acid
VHL Ligand-Linker Conjugates 16
E3 Ligase Ligand-Linker Conjugates 58
L-Prolinamide, N-(18-carboxy-1-oxo-4,7,10,13,16-pentaoxaoctadec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- | [Molecular Formula]
C36H54N4O11S | [MDL Number]
MFCD32693900 | [MOL File]
2172820-14-1.mol | [Molecular Weight]
750.9 |
| Hazard Information | Back Directory | [Uses]
(S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology[1]. | [Biological Activity]
(S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology[1]. | [IC 50]
VHL | [storage]
-20°C, stored under nitrogen | [References]
[1]. Chi JJ, et al. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Oct 25. pii: S2352-3964(19)30677-2. |
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