| Identification | Back Directory | [Name]
LIT-927 | [CAS]
2172879-52-4 | [Synonyms]
CS-2869
LIT-927
2(1H)-Pyrimidinone, 4-(4-chlorophenyl)-6-(4-hydroxy-3-methoxyphenyl)- | [Molecular Formula]
C17H13ClN2O3 | [MDL Number]
MFCD31726172 | [MOL File]
2172879-52-4.mol | [Molecular Weight]
328.75 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:66.0(Max Conc. mg/mL);200.76(Max Conc. mM) | [form ]
A solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biochem/physiol Actions]
LIT-927 is an orally active CXCL12 (SDF1) neutraligand (Kd = 267) that selectively neutralizes CXCL12, but not CCL17, CCL22, CCL5, or CCL2 activity in cultures (10 μM LIT-927 against 5 nM chemokine-induced calcium mobilization). LIT-927 reduces eosinophil recruitment in a murine allergic airway hypereosinophilia model in vivo (330 nmol/kg intranasal, 350 nmol/kg ip. or 1400 μmol/kg po.), offering greatly improved oral activity and solubility than Chalcone-4, and exhibiting little side-effects when compared with dexamethasone or CXCR4 antagonist AMD3100. |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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