| Chemical Properties | Back Directory | [Boiling point ]
913.1±65.0 °C(Predicted) | [density ]
1.149±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [pka]
14.36±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
PEG21-Tos is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions. | [Uses]
PEG20-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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