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2180923-05-9

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2180923-05-9 Structure

2180923-05-9 Structure
IdentificationBack Directory
[Name]

Bcl-2/Bcl-xl inhibitor 1
[CAS]

2180923-05-9
[Synonyms]

APG-2575
Lisaftoclax
APG-2575 (lisaftoclax)
Bcl-2/Bcl-xl inhibitor 1
[Molecular Formula]

C45H48ClN7O8S
[MDL Number]

MFCD34469554
[MOL File]

2180923-05-9.mol
[Molecular Weight]

882.42
Chemical PropertiesBack Directory
[density ]

1.48±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

4.07±0.10(Predicted)
[color ]

Light yellow to yellow
[InChIKey]

FNBXDBIYRAPDPI-BHVANESWSA-N
[SMILES]

C(NS(C1=CC=C(NC[C@H]2COCCO2)C([N+]([O-])=O)=C1)(=O)=O)(=O)C1=CC=C(N2CCN(CC3CCC4(CCC4)CC=3C3=CC=C(Cl)C=C3)CC2)C=C1OC1=CN=C2NC=CC2=C1
Hazard InformationBack Directory
[Uses]

Lisaftoclax (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Lisaftoclax exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively[1].
[IC 50]

Bcl-2: 2 nM (IC50); Bcl-xL: 5.9 nM (IC50)
[References]

[1] WANG, Chia, et al. N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS. Patent. WO2018027097A1.
Spectrum DetailBack Directory
[Spectrum Detail]

Bcl-2/Bcl-xl inhibitor 1(2180923-05-9)1HNMR
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