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2180923-05-9

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2180923-05-9 Structure

2180923-05-9 Structure
IdentificationBack Directory
[Name]

Bcl-2/Bcl-xl inhibitor 1
[CAS]

2180923-05-9
[Synonyms]

APG-2575
Lisaftoclax
APG-2575 (lisaftoclax)
Bcl-2/Bcl-xl inhibitor 1
[Molecular Formula]

C45H48ClN7O8S
[MDL Number]

MFCD34469554
[MOL File]

2180923-05-9.mol
[Molecular Weight]

882.42
Chemical PropertiesBack Directory
[density ]

1.48±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

4.07±0.10(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

Lisaftoclax (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Lisaftoclax exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively[1].
[IC 50]

Bcl-2: 2 nM (IC50); Bcl-xL: 5.9 nM (IC50)
[References]

[1] WANG, Chia, et al. N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS. Patent. WO2018027097A1.
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