| Identification | Back Directory | [Name]
Ethyl2,6-PyridinedicarboxylateMono | [CAS]
21855-16-3 | [Synonyms]
6-(Ethoxycarbonyl)
Methyl dipicolinate
6-(Ethoxycarbonyl)picolinic acid
Ethyl2,6-PyridinedicarboxylateMono
2,6-pyridinedicarboxylatemonoethylester
6-Ethoxycarbonyl-2-pyridinecarboxylic acid
2,6-Pyridinedicarboxylic acid, 2-ethyl ester
2,6-pyridinediCarbocylic acid monoethyl ester | [Molecular Formula]
C9H9NO4 | [MDL Number]
MFCD00806154 | [MOL File]
21855-16-3.mol | [Molecular Weight]
195.17 |
| Chemical Properties | Back Directory | [Melting point ]
116-117℃ | [Boiling point ]
396.2±27.0 °C(Predicted) | [density ]
1.304±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
3.27±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
The general synthetic procedure was as follows. 2,6-Pyridinedicarboxylic acid (1, 1.5 g, 8.98 mmol) was mixed with 24 mL of dichlorosulfoxide (SOCl2). The reaction mixture was heated to reflux for 3 hours. After completion of the reaction, excess dichlorosulfoxide was removed by distillation under reduced pressure. To the resulting white solid, 50 mL of tetrahydrofuran (THF) was added. After the solid was completely dissolved, ethanol (10.5 mmol) and N,N-diisopropylethylamine (DIEA, 10.5 mmol) were added slowly via syringe. The reaction mixture was heated to reflux for 4 hours. At the end of the reaction, the solvent was removed by distillation under reduced pressure. The residue was separated and purified by column chromatography to afford the target products diethyl 2,6-pyridinedicarboxylate and monoethyl 2,6-pyridinedicarboxylate. | [References]
[1] Tetrahedron, 2011, vol. 67, # 44, p. 8458 - 8464 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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