| Identification | Back Directory | [Name]
2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE | [CAS]
219138-24-6 | [Synonyms]
p38 MAPK Inhibitor
P38 MAP KINASE INHIBITOR
2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1H-pyrazol-3-one
2-(4-CHLOROPHENYL)-4-(FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE
2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE | [Molecular Formula]
C20H13ClFN3O | [MDL Number]
MFCD03452698 | [MOL File]
219138-24-6.mol | [Molecular Weight]
365.79 |
| Chemical Properties | Back Directory | [Boiling point ]
534.1±60.0 °C(Predicted) | [density ]
1.388±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 0.3 mg/ml | [form ]
A crystalline solid | [pka]
6.61±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
p38 MAPK-IN-4 (compound 6) is a p38 MAPK inhibitor with an 50 of 35 nM[1]. | [Biological Activity]
Cell permeable: no''Product does not compete with ATP.''Reversible: no | [IC 50]
p38: 35 nM (IC50) | [References]
[1] S E de Laszlo, et al. Pyrroles and other heterocycles as inhibitors of p38 kinase. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2689-94. DOI:10.1016/s0960-894x(98)00495-8 |
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