ChemicalBook--->CAS DataBase List--->21917-76-0

21917-76-0

21917-76-0 Structure

21917-76-0 Structure
IdentificationBack Directory
[Name]

2-METHYL-1,3-THIAZOLE-4-CARBONITRILE
[CAS]

21917-76-0
[Synonyms]

BUTTPARK 43\57-58
2-Methyl-4-cyanothiazole
4-Cyano-2-methyl-1,3-thiazole
2-methylthiazol-4-carbonitrile
2-METHYLTHIAZOLE-4-CARBONITRILE
2-Methyl-4-thiazolecarbonitrile
4-THIAZOLECARBONITRILE, 2-METHYL-
2-Methyl-1,3-thiazole-4-carbonitile
2-METHYL-1,3-THIAZOLE-4-CARBONITRILE
[Molecular Formula]

C5H4N2S
[MDL Number]

MFCD00068103
[MOL File]

21917-76-0.mol
[Molecular Weight]

124.16
Chemical PropertiesBack Directory
[Melting point ]

58-61°C
[Boiling point ]

229.4±13.0℃ (760 Torr)
[density ]

1.25±0.1 g/cm3 (20 ºC 760 Torr)
[Fp ]

92.5±19.8℃
[storage temp. ]

2-8°C
[Appearance]

Light brown to brown Solid
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

20/21/22-41
[Safety Statements ]

23-36/37/39-39-26
[RIDADR ]

3276
[Hazard Note ]

Irritant
[HS Code ]

2934100090
Hazard InformationBack Directory
[Definition]

ChEBI: 2-Methyl-1,3-thiazole-4-carbonitrile is a member of thiazoles.
[Synthesis]

2-Methylthiazole-4-carboxamide

31825-95-3

2-METHYL-1,3-THIAZOLE-4-CARBONITRILE

21917-76-0

The general procedure for synthesizing 2-methyl-1,3-thiazole-4-carbonitrile from 2-methylthiazole-4-carboxamide is as follows: general method: after completing the preparation of the amide intermediate, carry out the operation in Example A. According to the relationship between the boiling point of the amide intermediate and the reaction temperature TB, decide the state of the reaction vessel: if the boiling point of the amide intermediate at atmospheric pressure is equal to or lower than TB, close the reaction vessel; if the boiling point is higher than TB, keep the reaction vessel open. The stirring rate was maintained at 600 rpm, the reaction temperature was adjusted to TB and maintained at this temperature for TD hours until the reaction was nearly complete. Subsequently, the reaction vessel was sealed and connected to a vacuum pump, the vacuum in the reaction vessel was adjusted to 20-50 mbar (depending on the nature of the nitrile product) and the distillate was collected as the nitrile product. The yield was calculated and samples were taken for NMR spectroscopy and elemental analysis to characterize the obtained nitrile product. The specific reaction conditions and characterization results are detailed in Tables A-7, A-8, A-9, A-10, and A-11. The characterization results showed that the resulting nitrile product was of very high purity (over 99%). In some embodiments of the preparation of the nitrile product, 10 g of phosphorus pentoxide was selectively added as a catalyst at the initial stage of the reaction.

[References]

[1] Patent: CN104557357, 2018, B. Location in patent: Paragraph 0150; 0151; 0152; 0162
[2] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 6, p. 628 - 633
[3] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 8, p. 1203 - 1208
[4] Patent: WO2011/106414, 2011, A1. Location in patent: Page/Page column 83
[5] Journal of the Chemical Society [Section] C: Organic, 1969, p. 707 - 710
Spectrum DetailBack Directory
[Spectrum Detail]

2-METHYL-1,3-THIAZOLE-4-CARBONITRILE(21917-76-0)1HNMR
21917-76-0 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Website: www.chemicalbook.com/ShowSupplierProductsList454175/0_EN.htm
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: +86-0551-65418671 +8618949823763 , +8618949823763
Website: www.tnjchem.com
Company Name: Wuxi Rejoys chemical Technology Co., Ltd.
Tel: 0510-86103381
Website: www.rejoyschem.com
Company Name: Dayang Chem (Hangzhou) Co.,Ltd.
Tel: +86-0571-88938639 +8617705817739 , +8617705817739
Website: www.dycnchem.com/
Company Name: Golden Pharma Co., Limited
Tel: +undefined18958062155 , +undefined18958062155
Website: http://www.zjgoldpharm.com/
Company Name: PT CHEM GROUP LIMITED
Tel: +86-85511178;
Website: https://www.chemicalbook.com/manufacturer/henan-lihao-chem-plant-25020/
Company Name: GIHI CHEMICALS CO.,LIMITED
Tel: +8618058761490 , +8618058761490
Website: www.gihichem.com/
Company Name: Aceschem Inc.
Tel: +1-817863-6948 +1-(817)863-6948 , +1-(817)863-6948
Website: www.aceschem.com/
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873 , +86-86-13650506873
Website: http://www.chemdad.com/
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: ABCR GmbH & CO. KG
Tel: 49 721 95061 0
Website: www.abcr.de
Company Name: J & K SCIENTIFIC LTD.  
Tel: 18210857532
Website: www.jkchemical.com
Company Name: Meryer (Shanghai) Chemical Technology Co., Ltd.  
Tel: 021-61259108 18621169109
Website: https://www.meryer.com/cn/index/
Company Name: Pure Chemistry Scientific Inc.  
Tel: 001-857-928-2050 or 1-888-588-9418
Website: www.chemreagents.com
Company Name: Shanghai Harvest Chemical Industrial Co., Ltd.  
Tel: 21-31038972 15721252604
Website: www.harvest-chem.com/
Company Name: Nanjing Chemlin Chemical Co., Ltd  
Tel: 025-83697070
Website: www.echemlin.cn
Tags:21917-76-0 Related Product Information
65645-56-9 914358-72-8 3256-89-1 14186-60-8 35272-15-2 1211537-69-7 5156-01-4 136663-21-3 71825-51-9 56278-50-3

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.