| Identification | Back Directory | [Name]
(E)-2-Pyridinecarbaldehyde (2-pyridyl)hydrazone | [CAS]
21945-37-9 | [Synonyms]
MS0017509
MS-0017509
MS 0017509
E-pyridine-2-carbaldehyde 2-pyridylhydrazone
(E)-2-Pyridinecarbaldehyde (2-pyridyl)hydrazone
N-[(E)-pyridin-2-ylmethylideneamino]pyridin-2-amine | [Molecular Formula]
C11H10N4 | [MOL File]
21945-37-9.mol |
| Hazard Information | Back Directory | [Description]
MS0017509 is an inhibitor of DNA damage repair. | [Uses]
(E)-MS0019266 is a potent inhibitor of DNA damage repair. (E)-MS0019266 inhibits ribonucleotide reductase by generating reactive oxygen species. (E)-MS0019266 also reduces expression of genes related to cell cycle arrest and mitosis, including polo-like kinase 1, kinesin family member 20a, cyclin B1 and aurora kinase A. (E)-MS0019266 is promising for research of inhibitors of ribonucleotide reductase and polo-like kinase 1[1]. | [References]
[1] Fu S, et al. γ-H2AX kinetics as a novel approach to high content screening for small molecule radiosensitizers. PLoS One. 2012;7(6):e38465. DOI:10.1371/journal.pone.0038465 |
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