| Identification | Back Directory | [Name]
1-BOC-6-AMINO-INDAZOLE | [CAS]
219503-81-8 | [Synonyms]
1-BOC-6-AMINO-INDAZOLE
1-Boc-1H-indazol-6-amine
6-Amino-1H-indazole, N1-BOC
1-Boc-6-amino-1H-indazole,97%
6-Amino-1H-indazole, N1-BOC protected
6-AMINO-1-N-TERT-BUTOXYCARBONYL-1H-INDAZOLE
tert-butyl 6-amino-1H-indazole-1-carboxylate
6-AMINO-INDAZOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
6-AMINO-1H-INDAZOLE-1-CARBOXYLIC ACID, 1,1 DIMETHYL ETHYL ESTER
1H-Indazole-1-carboxylic acid, 6-aMino-, 1,1-diMethylethyl ester
tert-Butyl 6-amino-1H-indazole-1-carboxylate, 6-Amino-1-(tert-butoxycarbonyl)-1H-indazole | [Molecular Formula]
C12H15N3O2 | [MDL Number]
MFCD04114657 | [MOL File]
219503-81-8.mol | [Molecular Weight]
233.27 |
| Chemical Properties | Back Directory | [Melting point ]
171-172℃ | [Boiling point ]
395.3±34.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
powder | [pka]
2.52±0.10(Predicted) | [color ]
Yellow | [Water Solubility ]
Slightlysoluble in water. |
| Hazard Information | Back Directory | [Uses]
Used in the synthesis of chiral molecules. | [Synthesis]
Step B: Preparation of tert-butyl 6-amino-1H-indazole-1-carboxylate: To a solution of tert-butyl 6-nitro-1H-indazole-1-carboxylate (0.88 g, 3.34 mmol) in methanol (20 mL) was added 10% Pd/C catalyst (0.355 g, 0.334 mmol). After displacing the air in the reaction system with nitrogen, the hydrogenation reaction was carried out under hydrogen (30 psi) atmosphere for 2 hours. After completion of the reaction, the reaction mixture was filtered through GF/F filter paper and the filtrate was concentrated to afford the target product tert-butyl 6-amino-1H-indazole-1-carboxylate (0.76 g, 98% yield). Mass spectrometry analysis (APCI-positive ion mode) showed [M+1]+ peak of 233.8. | [References]
[1] Patent: US2010/63066, 2010, A1. Location in patent: Page/Page column 35
[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 4, p. 944 - 954
[3] Patent: US6372759, 2002, B1
[4] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 13, p. 3821 - 3830
[5] Asian Journal of Chemistry, 2014, vol. 26, # 22, p. 7539 - 7543 |
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