| Identification | Back Directory | [Name]
methyl 3-amino-5-chlorobenzoate | [CAS]
21961-31-9 | [Synonyms]
methyl 3-amino-5-chlorobenzoate
Methyl3-amino-5-chlorobenzoate98%
Methyl 3-amino-5-chlorobenzoate 98%
3-AMINO-5-CHLORO-BENZOIC ACID METHYL ESTER
Benzoic acid, 3-aMino-5-chloro-, Methyl ester | [Molecular Formula]
C8H8ClNO2 | [MDL Number]
MFCD11053764 | [MOL File]
21961-31-9.mol | [Molecular Weight]
185.61 |
| Chemical Properties | Back Directory | [Boiling point ]
329.4±22.0 °C(Predicted) | [density ]
1.311±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
2.39±0.10(Predicted) | [Appearance]
White to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
Step 2: Synthesis of methyl 3-amino-5-chlorobenzoate
A dioxane solution (0.13 M) of methyl 3-chloro-5-nitrobenzoate (from Step 1) was placed in a reaction flask and SnCl2 (3.9 equiv) was added. The reaction mixture was stirred at 70 °C for 2 hours. After completion of the reaction, it was cooled to room temperature and EtOAc and saturated aqueous NaHCO3 solution was added. The reaction mixture was filtered to remove the precipitate formed. The aqueous phase was separated and extracted with EtOAc. All organic layers were combined and dried with anhydrous Na2SO4. Evaporation of the solvent under reduced pressure afforded the title compound methyl 3-amino-5-chlorobenzoate in 88% yield as a yellow solid. Mass spectrum (ES+) m/z 186,188 (M+H)+. | [References]
[1] Patent: WO2007/28789, 2007, A1. Location in patent: Page/Page column 35
[2] Patent: US2010/261687, 2010, A1. Location in patent: Page/Page column 60 |
|
| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
| Company Name: |
DebyeTec.com Inc.
|
| Telephone: |
18086626237 18086626237 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList16955/0.htm |
| Company Name: |
NovoChemy Ltd.
|
| Telephone: |
86-(0)21-31261262 373522135 |
| Website: |
www.novochemy.com |
|