2196199-00-3

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2196199-00-3 Structure

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[Name] CZh226
[CAS] 2196199-00-3
[Synonyms] CZh226
[Molecular Formula] C20H22ClN7O
[MDL Number] MFCD32868917
[MOL File] 2196199-00-3.mol
[Molecular Weight] 411.89

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[Description]

CZh226 is a potent and selective PAK4 inhibitor (PAK4 Ki = 9 nM; PAK1 Ki = 3112 nM). CZh226 showed remarkable PAK4 selectivity (346-fold vs PAK1) and favorable kinase selectivity profile. CZh226 potently inhibited the migration and invasion of A549 tumor cells by regulating the PAK4-directed downstream signaling pathways in vitro. CZh226 as a lead compound for PAK4-targeted anticancer drug discovery and as a valuable research probe for the further biological investigation of group II PAKs.

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Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

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2196199-00-3

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