| Identification | Back Directory | [Name]
GUANIDINYL NALTRINDOLE | [CAS]
219655-57-9 | [Synonyms]
5'guanidinonaltrindole bis(trifluoroacetate)
5'-Guanidinonaltrindole di(trifluoroacetate)
5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate
5μ-Guanidinonaltrindole hydrate di(trifluoroacetate) salt | [Molecular Formula]
C27H29N5O3 | [MDL Number]
MFCD03788471 | [MOL File]
219655-57-9.mol | [Molecular Weight]
471.558 |
| Hazard Information | Back Directory | [Uses]
5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate (GNTI) has been used as a selective κ opioid receptor antagonist:
- to study the influence of opioid receptor types on the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitors in inflammation
- to study the role of κ opioid receptor in the forebrain-dependent associative task, Whisker-Trace Eyeblink conditioning (WTEB)
- to validate its inhibitory actions on Akt kinase activities
| [Uses]
5′-Guanidinonaltrindole di(trifluoroacetate) Salt is a selective opioid receptor antagonist. It has also been utilized to develop fluorescent methods to identify phosphopantetheinyl transferase inhibitors. | [Biochem/physiol Actions]
5′-Guanidinonaltrindole di(trifluoroacetate) (GNTI) is a 5‘-guanidine derivative and a selective κ opiate receptor antagonist. It is five-fold more potent and 500-fold more selective than norbinaltorphimine (nor-BNI) for the κ opioid receptor in smooth muscle preparations. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
SIGMA-RBI
|
| Tel: |
800 736 3690 (Orders) |
| Website: |
www.sigma-aldrich.com |
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