2198977-68-1

Directory

2198977-68-1 Structure

Identification	Back Directory
[Name] BPU17
[CAS] 2198977-68-1
[Synonyms] BPU17 Cyclobutanecarboxamide, N-[[(4-chlorophenyl)amino]carbonyl]-
[Molecular Formula] C12H13ClN2O2
[MOL File] 2198977-68-1.mol
[Molecular Weight] 252.7

Chemical Properties	Back Directory
[density ] 1.373±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 12.42±0.20(predicted)

Hazard Information	Back Directory
[Uses] BPU17 binds to PHB1 and causes mild defects in mitochondrial function by defects in the PHB1-PHB2 interaction. This impairment inhibits the SRF/CArG-box-dependent transcription, resulting in the suppression of epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs). BPU17 exhibits antifibrotic activity in vivo. BPU17 is promising for research of anti-neovascular age-related macular degeneration (nAMD) agent[1].
[References] [1] Hayashi K, et al. The benzoylphenylurea derivative BPU17 acts as an inhibitor of prohibitin and exhibits antifibrotic activity. Exp Cell Res. 2024 Sep 1;442(1):114221. DOI:10.1016/j.yexcr.2024.114221

2198977-68-1 suppliers list

Tags:2198977-68-1 Related Product Information

HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

Login