| Identification | Back Directory | [Name]
Bisnorcymserine | [CAS]
219920-81-7 | [Synonyms]
Bisnorcymserine
N1N8Bisnorcymserine
N1-N8-Bisnorcymserine
N1 N8 Bisnorcymserine
Carbamic acid, N-[4-(1-methylethyl)phenyl]-, (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-3a-methylpyrrolo[2,3-b]indol-5-yl ester | [Molecular Formula]
C21H25N3O2 | [MOL File]
219920-81-7.mol | [Molecular Weight]
351.44 |
| Hazard Information | Back Directory | [Uses]
Bisnorcymserine ((-)-Bisnorcymserine) is an inhibitor for butyrylcholinesterase (BChE) with an IC50 of 0.228 nM. Bisnorcymserine reduces the levels of amyloid-β peptide (Aβ), exhibits ameliorates the Alzheimer’s Disease in elderly rat models. Bisnorcymserine is blood-brain barrier penetrate[1]. | [IC 50]
BChE: 0.228 nM (IC50) | [References]
[1] Kamal MA, et al., Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnorcymserine. J Alzheimers Dis. 2006 Sep;10(1):43-51. DOI:10.3233/jad-2006-10108 |
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