| Identification | Back Directory | [Name]
N-[4-[[1-(2-Amino-4-hydroxy-6-pteridinyl)ethyl]methylamino]benzoyl]-L-glutamic acid | [CAS]
22006-84-4 | [Synonyms]
Dimetfol
Denopterin
9-Dimethylfolic acid
N10,9-Dimethylfolic acid
N-[4-[[1-(2-Amino-4-hydroxy-6-pteridinyl)ethyl]methylamino]benzoyl]-L-glutamic acid
L-Glutamic acid, N-[4-[[1-(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)ethyl]methylamino]benzoyl]- | [Molecular Formula]
C21H23N7O6 | [MOL File]
22006-84-4.mol | [Molecular Weight]
469.45 |
| Hazard Information | Back Directory | [Uses]
Denopterin is a dihydrofolate reductase (DHFR) inhibitor and an antifolate agent. Denopterin is an antimetabolite that has toxic effects on cells and can be used for cancer[1]. | [IC 50]
VHL | [References]
[1] Robert Yongxin Zhao, et al. Cross-linked pyrrolobenzodiazepine dimer (pbd) derivative and its conjugates. WO2020006722A1 |
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