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220290-68-6

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220290-68-6 Structure

220290-68-6 Structure
IdentificationBack Directory
[Name]

2-oxa-6-azaspiro[3.4]octane
[CAS]

220290-68-6
[Synonyms]

2-oxa-6-azaspiro[3.4]octane
2-oxa-7-azaspiro[3.4]octane
2-Oxa-6-azaspiro[3.4]octa...
2-Oxa-6-azaspiro[3.4]octane,95%
2-oxa-6-azaspiro[3.4]octane, hemioxalate salt
[Molecular Formula]

C6H11NO
[MDL Number]

MFCD14586455
[MOL File]

220290-68-6.mol
[Molecular Weight]

113.158
Chemical PropertiesBack Directory
[Boiling point ]

187℃
[density ]

1.08
[Fp ]

63°(145°F)
[storage temp. ]

Keep in dark place,Sealed in dry,2-8°C
[pka]

10.55±0.20(Predicted)
[Water Solubility ]

Soluble in water.
[InChI]

InChI=1S/C6H11NO/c1-2-7-3-6(1)4-8-5-6/h7H,1-5H2
[InChIKey]

ZHAIMJRKJKQNQI-UHFFFAOYSA-N
[SMILES]

C1C2(CCNC2)CO1
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Danger
[Hazard statements ]

H227-H315-H319-H335
[Precautionary statements ]

P210e-P261-P280a-P305+P351+P338-P405-P501a
[HS Code ]

29339900
Hazard InformationBack Directory
[Uses]

2-Oxa-6-azaspiro[3.4]octane is involved in the preparation of azaspirocycle or azetidine substituted 4-anilinoquinazoline derivatives, which exhibits epidermal growth factor receptor (EGFR) inhibitory activities.
[Application]

2-Oxa-6-Azaspiro[3.4]Octane Hydrochloride may be useful in the preparation of aminocyanopyridine derivatives for the prevention or treatment of cancer or inflammatory diseases.
[Synthesis]

Tert-butyl 2-oxa-6-azaspiro[3.4]octane-6-carboxylate (86mg, 0.4mmol) was dissolved in dichloromethane (1mL), trifluoroacetic acid (2mL) was added to the system at room temperature, and the reaction solution was heated at 60°C for 2h. The reaction solution was cooled to room temperature and concentrated under reduced pressure to obtain crude product 2-oxa-6-azaspiro[3.4]octane.
2-oxa-6-azaspiro[3.4]octane
Spectrum DetailBack Directory
[Spectrum Detail]

2-oxa-6-azaspiro[3.4]octane(220290-68-6)1HNMR
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