| Identification | Back Directory | [Name]
N-[3-(Bromomethyl)benzyl]carbamic acid tert-butyl ester | [CAS]
220364-34-1 | [Synonyms]
tert-Butyl 3-(bromomethyl)
3-(Boc-aMinoMethyl)benzylbroMide
tert-Butyl 3-(broMoMethyl)benzylcarbaMate
1-[3-(Bromomethyl)phenyl]-N-Boc-methanamine
3-(tert-Butoxycarbonylaminomethyl)benzyl bromide
tert-butyl N-[[3-(bromomethyl)phenyl]methyl]carbamate
[3-(Bromomethyl)benzyl]carbamic acid tert-butyl ester
N-[3-(Bromomethyl)benzyl]carbamic acid tert-butyl ester
Carbamic acid, N-[[3-(bromomethyl)phenyl]methyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C13H18BrNO2 | [MDL Number]
MFCD20257493 | [MOL File]
220364-34-1.mol | [Molecular Weight]
300.19 |
| Chemical Properties | Back Directory | [Boiling point ]
390.9±30.0 °C(Predicted) | [density ]
1.304 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
12.11±0.46(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of tert-butyl 3-(bromomethyl)benzylcarbamate from tert-butyl (3-hydroxymethyl-benzyl)-carboxylate: Boc-aminomethylbenzyl alcohol (237 mg), triphenylphosphine (485 mg), and carbon tetrabromide (491 mg) were dissolved in dichloromethane (10 mL) and the reaction was stirred at room temperature overnight. After completion of the reaction, the reaction solution was concentrated. The crude product was purified by silica gel column chromatography to afford the target product tert-butyl 3-(bromomethyl)benzylcarbamate (200 mg, 67% yield). | [References]
[1] Patent: US2006/173183, 2006, A1. Location in patent: Page/Page column 113
[2] Patent: WO2005/18557, 2005, A2. Location in patent: Page/Page column 282-283
[3] Patent: WO2005/18557, 2005, A2. Location in patent: Page/Page column 282-283
[4] Patent: EP1452521, 2004, A1. Location in patent: Page 55 |
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