| Identification | Back Directory | [Name]
Leptomerine | [CAS]
22048-97-1 | [Synonyms]
lepomerine
4(1H)-Quinolinone, 1-methyl-2-propyl- | [Molecular Formula]
C13H15NO | [MDL Number]
MFCD28336213 | [MOL File]
22048-97-1.mol | [Molecular Weight]
201.26 |
| Chemical Properties | Back Directory | [Boiling point ]
300.4±42.0 °C(Predicted) | [density ]
1.063±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
2.56±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer Disease. Leptomerine inhibits acetyl cholinesterase (AChE) with an IC50 of 2.5 μM. Anticholinesterasic activity[1]. | [References]
[1] Cardoso-Lopes EM, et al. Alkaloids from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer disease. Molecules. 2010 Dec 13;15(12):9205-13. DOI:10.3390/molecules15129205 |
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