| Identification | Back Directory | [Name]
(S)-2-(2-chloro-6-methylbenzamido)-3-(4-(2,6-dichlorobenzamido)phenyl)propanoic acid(WXG00491) | [CAS]
220846-33-3 | [Synonyms]
L-Phenylalanine, N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlorobenzoyl)amino]- (S)-2-(2-chloro-6-methylbenzamido)-3-(4-(2,6-dichlorobenzamido)phenyl)propanoic acid (S)-2-(2-chloro-6-methylbenzamido)-3-(4-(2,6-dichlorobenzamido)phenyl)propanoic acid(WXG00491) | [Molecular Formula]
C24H19Cl3N2O4 | [MDL Number]
MFCD34471456 | [MOL File]
220846-33-3.mol | [Molecular Weight]
505.778 |
| Chemical Properties | Back Directory | [Boiling point ]
633.0±55.0 °C(Predicted) | [density ]
1.447±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
3.60±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. Antiinflammatory activity[1][2]. | [in vivo]
In a murine OVA-model of airway inflammation, RO0270608 i.n. abolishes allergen-induced inflammatory cell accumulation[2] | [IC 50]
α4β1; α4β7 | [storage]
Store at -20°C | [References]
[1] Hijazi Y, et al. Pharmacokinetics, safety, and tolerability of R411, a dual alpha4beta1-alpha4beta7 integrin antagonist after oral administration at single and multiple once-daily ascending doses in healthy volunteers. J Clin Pharmacol. 2004;44(12):1368-1 DOI:10.1177/0091270004270147 [2] M. Renzetti, et al. Dual α4/β1–α4/β7 vs α4/β1 selective antagonism is required for attenuation of allergic inflammatory responses. Journal of Allergy and Clinical Immunology. Volume 113, Issue 2, Supplement, February 2004, Page S221. |
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