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220997-99-9

220997-99-9 Structure

220997-99-9 Structure
IdentificationBack Directory
[Name]

BN 80927
[CAS]

220997-99-9
[Synonyms]

BN 80927
Elomotecan HCl salt
EloMotecan (hydrochloride)
OLYFGLXPXPABOP-XXIQNXCHSA-N
[Molecular Formula]

C29H33Cl2N3O4
[MOL File]

220997-99-9.mol
[Molecular Weight]

558.5
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Elomotecan hydrochloride (BN 80927) is a potent inhibitor of topoisomerases I and II. Elomotecan hydrochloride (BN 80927) is a camptothecin analog belonging to the homocamptothecin family (hCPT). Elomotecan hydrochloride (BN 80927) reduces the proliferation of different tumor cells with higher potency than other anticancer agents of reference targeting topoisomerases I and II[1].
[IC 50]

Topoisomerase I; Topoisomerase II
[References]

[1] Trocóniz IF, et al. Population pharmacokinetic/pharmacodynamic modeling of drug-induced adverse effects of a novel homocamptothecin analog, elomotecan (BN80927), in a Phase I dose finding study in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2012;70(2):239-250. DOI:10.1007/s00280-012-1906-y
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