Identification | Back Directory | [Name]
BN 80927 | [CAS]
220997-99-9 | [Synonyms]
BN 80927 Elomotecan HCl salt EloMotecan (hydrochloride) OLYFGLXPXPABOP-XXIQNXCHSA-N | [Molecular Formula]
C29H33Cl2N3O4 | [MOL File]
220997-99-9.mol | [Molecular Weight]
558.5 |
Hazard Information | Back Directory | [Uses]
Elomotecan hydrochloride (BN 80927) is a potent inhibitor of topoisomerases I and II. Elomotecan hydrochloride (BN 80927) is a camptothecin analog belonging to the homocamptothecin family (hCPT). Elomotecan hydrochloride (BN 80927) reduces the proliferation of different tumor cells with higher potency than other anticancer agents of reference targeting topoisomerases I and II[1]. | [IC 50]
Topoisomerase I; Topoisomerase II | [References]
[1] Trocóniz IF, et al. Population pharmacokinetic/pharmacodynamic modeling of drug-induced adverse effects of a novel homocamptothecin analog, elomotecan (BN80927), in a Phase I dose finding study in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2012;70(2):239-250. DOI:10.1007/s00280-012-1906-y |
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