| Identification | Back Directory | [Name]
2-(4-ETHOXYFENYL)-3-(4-MESYLFENYL)PYRAZOLO[1,5-B]PYRIDAZINE | [CAS]
221148-46-5 | [Synonyms]
GW 406381
GW 406381 - GW 406381X
2-(4-ETHOXYFENYL)-3-(4-MESYLFENYL)PYRAZOLO[1,5-B]PYRIDAZINE
Pyrazolo[1,5-b]pyridazine, 2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]- | [Molecular Formula]
C21H19N3O3S | [MDL Number]
MFCD09475687 | [MOL File]
221148-46-5.mol | [Molecular Weight]
393.46 |
| Chemical Properties | Back Directory | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO, sonicated:25.0(Max Conc. mg/mL);63.0(Max Conc. mM) | [form ]
A solid | [pka]
0.65±0.30(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
GW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury[1][2]. | [IC 50]
COX-2 | [storage]
Store at -20°C | [References]
[1] Zhao FY, et al. GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. Pain. 2007 Mar;128(1-2):78-87. DOI:10.1016/j.pain.2006.08.032
[2] Boswell DJ, et al. Evaluation of GW406381 for treatment of osteoarthritis of the knee: two randomized, controlled studies. Medscape J Med. 2008;10(11):259. PMID:19099009 |
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