| Identification | Back Directory | [Name]
Acetamide, 2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methyl-d3-sulfonyl)phenyl]ethyl]- | [CAS]
2211914-19-9 | [Synonyms]
Acetamide, 2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methyl-d3-sulfonyl)phenyl]ethyl]- | [Molecular Formula]
C12H15Cl2NO5S | [MOL File]
2211914-19-9.mol | [Molecular Weight]
356.21 |
| Hazard Information | Back Directory | [Uses]
Thiamphenicol-d3 is a deuterium labeled Thiamphenicol. Thiamphenicol, a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria)[1][2]. | [References]
[1] A Marchese, et al. In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy. J Chemother. 2002 Dec;14(6):554-61. DOI:10.1179/joc.2002.14.6.554
[2] Marta Tikhomirov, et al. Pharmacokinetics of florfenicol and thiamphenicol in ducks. J Vet Pharmacol Ther. 2019 Jan;42(1):116-120. DOI:10.1111/jvp.12714 |
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