| Identification | Back Directory | [Name]
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 6-chloro-N-cyclopentyl-1-[5-O-(phosphonomethyl)-β-D-ribofuranosyl]- | [CAS]
2216764-29-1 | [Synonyms]
CD73-IN-4
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 6-chloro-N-cyclopentyl-1-[5-O-(phosphonomethyl)-β-D-ribofuranosyl]-
methylenephosphonic,CD73IN4,inhibit,CD73 IN 4,CD73,immunology,Inhibitor,CD-73-IN-4,5'-Ribonucleotide phosphohydrolase,cluster,differentiation,cancer,acid | [Molecular Formula]
C16H23ClN5O7P | [MDL Number]
MFCD33548889 | [MOL File]
2216764-29-1.mol | [Molecular Weight]
463.81 |
| Chemical Properties | Back Directory | [density ]
1.97±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (269.51 mM; Need ultrasonic) | [form ]
Solid | [pka]
2.40±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor, with an IC50 of 2.6 nM for human CD73. CD73-IN-4 is potential for the research of cancer immunology[1]. | [References]
[1] Ehesan U Sharif , et al. Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors. J Med Chem. 2021 Jan 5. DOI:10.1021/acs.jmedchem.0c01835 |
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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