| Identification | Back Directory | [Name]
Pentanoic acid, 5-[[(1S)-2-[(acetyloxy)methoxy]-1-methyl-2-oxoethyl]amino]-5-oxo-, methyl ester | [CAS]
2222067-12-9 | [Synonyms]
Pentanoic acid, 5-[[(1S)-2-[(acetyloxy)methoxy]-1-methyl-2-oxoethyl]amino]-5-oxo-, methyl ester | [Molecular Formula]
C12H19NO7 | [MOL File]
2222067-12-9.mol | [Molecular Weight]
289.28 |
| Hazard Information | Back Directory | [Uses]
Pro-GA is a γ-Glutamylcyclotransferase (GGCT) inhibitor and a cell-permeable diester-type pro-drug with anticancer activity, GGCT is a key enzyme in glutathione metabolism and is involved in the ferroptosis pathway. Pro-GA exhibits an IC50 of 57 μM against the bladder cancer cell line T24 and can be utilized in cancer research[1]. | [References]
[1] Hanada E, et al. Pro-GA, a Novel Inhibitor of γ-Glutamylcyclotransferase, Suppresses Human Bladder Cancer Cell Growth. Anticancer Res. 2019 Apr;39(4):1893-1898. DOI:10.21873/anticanres.13297 |
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