| Identification | Back Directory | [Name]
3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]- | [CAS]
2222112-77-6 | [Synonyms]
ARV-110
N-((1R,4R)-4-(3-chloro-4-cyanophenox
y)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopip
eridin-3-yl)-6-fluoro-1,3-dioxoisoindoli
n-5-yl)piperazin-1-yl)methyl)piperidin-1 -yl)pyridazine-3-carboxamide
3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]- | [Molecular Formula]
C41H43ClFN9O6 | [MDL Number]
MFCD34167542 | [MOL File]
2222112-77-6.mol | [Molecular Weight]
812.29 |
| Chemical Properties | Back Directory | [Boiling point ]
1074.1±65.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
Store at-20°C, away from moisture | [solubility ]
DMSO : 26.67 mg/mL (32.83 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 80°C) | [form ]
Solid | [pka]
10.59±0.40(Predicted) | [color ]
Light yellow to yellow | [InChIKey]
CLCTZVRHDOAUGJ-SYVGMNBRSA-N | [SMILES]
C1(C(N[C@@H]2CC[C@@H](OC3=CC=C(C#N)C(Cl)=C3)CC2)=O)=NN=C(N2CCC(CN3CCN(C4C(F)=CC5=C(C=4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)C=C1 |
| Hazard Information | Back Directory | [Description]
ARV-110 is an androgen receptor PROTAC degrader. It promotes ubiquitination and degradation of the androgen receptor. |
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