| Hazard Information | Back Directory | [Description]
ABBV-3221, also known as GLPG-3221, is a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis. | [Uses]
GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis[1]. | [in vivo]
GLPG-3221 (1 mg/kg; i.v.) treatment shows the?Cl and?t1/2?are 0.13 L/h/kg and?3?hours,?respectively[1].
GLPG-3221 (1 mg/kg; p.o.)treatment shows the F% value is 53%[1]. | Animal Model: | Rat[1] | | Dosage: | 1 mg/kg | | Administration: | i.v. administration?(Pharmacokinetic?Analysis) | | Result: | The?Cl and?t1/2?were 0.13 L/h/kg and?3?hours,?respectively. |
| [References]
[1] Scanio MJC, et al.Discovery?of?ABBV/GLPG-3221, a?Potent?Corrector?of?CFTR?for the Treatment of Cystic Fibrosis.ACS Med Chem Lett.?2019 Oct 31;10(11):1543-1548. DOI:10.1021/acsmedchemlett.9b00377 |
|
|