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2222354-61-0

2222354-61-0 Structure

2222354-61-0 Structure
IdentificationBack Directory
[Name]

SNIPER(ABL)-058
[CAS]

2222354-61-0
[Synonyms]

SNIPER(ABL)-058
Benzamide, 1-[[4-[2-[2-[2-[2-[3-[[2-[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]acetyl]-2-pyrrolidinyl]-4-thiazolyl]carbonyl]phenoxy]ethoxy]ethoxy]ethoxy]acetyl]-1-piperazinyl]methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-
[Molecular Formula]

C62H75N11O9S
[MDL Number]

MFCD32062722
[MOL File]

2222354-61-0.mol
[Molecular Weight]

1150.41
Chemical PropertiesBack Directory
[density ]

1.279±0.06 g/cm3(Predicted)
[pka]

13.28±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

SNIPER(ABL)-058, conjugating Imatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM[1].
[References]

[1] Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666. DOI:10.1111/cas.13284
2222354-61-0 suppliers list
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Company Name: Adooq Bioscience LLC  
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Website: http://www.adooq.cn
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