| Chemical Properties | Back Directory | [Boiling point ]
1748.4±65.0 °C(predicted) | [density ]
1.401±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
4.20±0.10(predicted) | [color ]
White to off-white | [Sequence]
{2-(3-chloro-4-fluorophenoxy)acetic acid}-Ser-Ala-Tyr-Pro-Asp-Ser-Val-Pro-{Nle}-{Hsr}-Ser-NH2 |
| Hazard Information | Back Directory | [Uses]
123B9, a tumor-homing agent, is a potent and selective EphA2 agonist with a Kd value of 4.0 μM. 123B9 selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain. 123B9 does not appreciably inhibit the ligand binding domains of the most closely related EphA3 and EphA4 receptors[1]. | [in vivo]
In mice, the mean plasma concentration over time following 123B9 IV administration (30 mg/kg) indicated that the compound is detectable in vivo at each time point tested (30 min, 1 hr, 2 hr, 4 hr) with a mean concentration in plasma of 447 ng/mL and 569 ng/mL still detectable at 2 hr and 4 hr, respectively[1]. | [References]
[1] Bainan Wu, et al. Design and Characterization of Novel EphA2 Agonists for Targeted Delivery of Chemotherapy to Cancer Cells. Chem Biol. 2015 Jul 23;22(7):876-887. DOI:10.1016/j.chembiol.2015.06.011 |
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| Company Name: |
YantaiBio
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| Tel: |
13758194781 15083780366 |
| Website: |
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| Company Name: |
Biorbyt Ltd.
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| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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