| Chemical Properties | Back Directory | [Boiling point ]
788.2±70.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (218.65 mM; Need ultrasonic) | [form ]
Solid | [pka]
14.94±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively. | [IC 50]
EGFR: 10.4 nM (IC50); EGFRL858R: 1.1 nM (IC50); EGFRL858R/T790M: 34 nM (IC50); EGFRL858R/T790M/C797S: 7.2 nM (IC50) | [References]
[1] Zhang H, et al. Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs. Eur J Med Chem. 2018 Mar 25;148:221-237. DOI:10.1016/j.ejmech.2018.02.051 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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