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2227303-22-0

2227303-22-0 Structure

2227303-22-0 Structure
IdentificationBack Directory
[Name]

Olean-12-en-29-oic acid, 3-[4-[(6-fluoro-2-benzothiazolyl)amino]-1,4-dioxobutoxy]-11-oxo-, ethyl ester, (3β,20β)-
[CAS]

2227303-22-0
[Synonyms]

HSP90-CDC37-IN-1
Olean-12-en-29-oic acid, 3-[4-[(6-fluoro-2-benzothiazolyl)amino]-1,4-dioxobutoxy]-11-oxo-, ethyl ester, (3β,20β)-
[Molecular Formula]

C43H57FN2O6S
[MDL Number]

MFCD31813636
[MOL File]

2227303-22-0.mol
[Molecular Weight]

748.99
Chemical PropertiesBack Directory
[density ]

1.23±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

9.74±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor that inhibit cell migration and reverse agent resistance, with an IC50 of 140 nM.
[References]

[1] Jin L, et al. Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance. Bioorg Med Chem. 2018 May 1;26(8):1759-1775. DOI:10.1016/j.bmc.2018.02.021
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