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2227315-30-0

2227315-30-0 Structure

2227315-30-0 Structure
IdentificationBack Directory
[Name]

1H-1,2,3-Triazole, 1-(4-methoxyphenyl)-4-[[2-methyl-5-(1-methylethyl)phenoxy]methyl]-
[CAS]

2227315-30-0
[Synonyms]

JMI-105
1H-1,2,3-Triazole, 1-(4-methoxyphenyl)-4-[[2-methyl-5-(1-methylethyl)phenoxy]methyl]-
[Molecular Formula]

C20H23N3O2
[MOL File]

2227315-30-0.mol
[Molecular Weight]

337.42
Chemical PropertiesBack Directory
[Boiling point ]

494.8±55.0 °C(Predicted)
[density ]

1.12±0.1 g/cm3(Predicted)
[pka]

-0.92±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

JMI-105 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-105 inhibits the growth of CQS (3D7; IC50=8.8 μM) and CQR (RKL-9; IC50=14.3 μM) strains of P. falciparum. JMI-105 significantly decreases parasitemia and prolonged host survival in a murine model with P. berghei ANKA infection. JMI-105 has the potential to be used as an anti-malarial agent[1].
[References]

[1] Uddin A, et al. Identification and structure-activity relationship (SAR) studies of carvacrol derivatives as potential anti-malarial against Plasmodium falciparum falcipain-2 protease. Bioorg Chem. 2020 Oct;103:104142. DOI:10.1016/j.bioorg.2020.104142
2227315-30-0 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Tel: 15076683720
Website: http://www.cw-bio.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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