| Identification | Back Directory | [Name]
1H-Indole-2-carboxylic acid, 7-[5-[[4-(4-acetyl-1-piperazinyl)phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-3-[3-[(5-fluoro-1-naphthalenyl)oxy]propyl]-1-[2-(4-morpholinyl)ethyl]- | [CAS]
2228052-37-5 | [Synonyms]
1H-Indole-2-carboxylic acid, 7-[5-[[4-(4-acetyl-1-piperazinyl)phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-3-[3-[(5-fluoro-1-naphthalenyl)oxy]propyl]-1-[2-(4-morpholinyl)ethyl]- | [Molecular Formula]
C46H51FN6O6 | [MOL File]
2228052-37-5.mol | [Molecular Weight]
802.93 |
| Hazard Information | Back Directory | [Uses]
A-1155905 is a MCL-1 inhibitor (IC50=33.5 nM; Ki=0.58 nM) with anticancer activity. A-1155905 selectively binds to MCL-1 with sufficient affinity to disrupt the MCL-1-bim complex in living cells. A-1155905-induced death of MCL-1-dependent cell lines is caspase-dependent and occurs via apoptosis[1]. | [References]
[1] Leverson, et al. "Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)." Cell death & disease 6.1 (2015): e1590-e1590. DOI:10.1038/cddis.2014.561 |
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