| Identification | Back Directory | [Name]
FLT3-IN-3 | [CAS]
2229050-90-0 | [Synonyms]
SAN50900
FLT3-IN-3
9H-Purine-2,6-diamine, N2-(trans-4-aminocyclohexyl)-9-cyclopentyl-N6-[4-(4-morpholinylmethyl)phenyl]-
inhibit,Fms like tyrosine kinase 3,FLT-3-IN-3,FLT3,CD135,Inhibitor,Cluster of differentiation antigen 135,FLT3IN3,FLT3 IN 3 | [Molecular Formula]
C27H38N8O | [MDL Number]
MFCD31813658 | [MOL File]
2229050-90-0.mol | [Molecular Weight]
490.64 |
| Chemical Properties | Back Directory | [Melting point ]
133-135 °C | [Boiling point ]
717.6±70.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 15 mg/ml; PBS (pH 7.2): insol | [form ]
A solid | [pka]
10.42±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
FLT3-IN-3 is a potent FLT3 inhibitor with IC50s of 13 and 8 nM for FLT3 WT and FLT3 D835Y, respectively. | [in vivo]
A single dose of FLT3-IN-3 (Compound 7d; 10 mg/kg; i.p.) in mice with subcutaneous MV4-11 xenografts causes sustained inhibition of FLT3 and STAT5 phosphorylation over 48 hours[1]. | Animal Model: | Female athymic nu/nu mice with subcutaneously implanted MV4-11 xenografts[1] | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal (i.p.) injection; 48 hours | | Result: | Effectively inhibited FLT3-ITD autophosphorylation in MV4-11 xenografts. |
| [storage]
Store at -20°C | [References]
[1] Gucky T, et al. Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl- N6-(4-morpholin-4-ylmethyl-phenyl)- 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations. J Med Chem. 2018 May 10;61(9):3855-3869. DOI:10.1021/acs.jmedchem.7b01529 |
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| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|