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2229716-11-2

2229716-11-2 Structure

2229716-11-2 Structure
IdentificationBack Directory
[Name]

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]-
[CAS]

2229716-11-2
[Synonyms]

2-(2,6-dioxopiperidin-3-yl)-5-(4-(piperidin-4-yl)piperazin-1-yl)isoindoline-1,3-dione
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinyl)-1-piperazinyl]-
[Molecular Formula]

C22H27N5O4
[MOL File]

2229716-11-2.mol
[Molecular Weight]

425.48
Chemical PropertiesBack Directory
[Boiling point ]

686.0±55.0 °C(Predicted)
[density ]

1.367±0.06 g/cm3(Predicted)
[pka]

10.83±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

Thalidomide-Piperazine-Piperidine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
[Biological Activity]

Thalidomide-Piperazine-Piperidine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[IC 50]

Cereblon
[References]

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008.
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