| Hazard Information | Back Directory | [Uses]
XPC-5462 is a NaV1.6 and NaV1.2 inhibitor with the IC50s of 10.9 nM and 10.3 nM, respectively. XPC-5462 suppresses epileptiform activity in an ex vivo brain slice seizure model[1]. | [IC 50]
Nav1.2: 10.3 nM (IC50); Nav1.6: 10.9 nM (IC50) | [References]
[1] Goodchild SJ,et al. Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo. ACS Chem Neurosci. 2024 Feb 15. DOI:10.1021/acschemneuro.3c00757 |
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